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Propofol 10mg/mL

weight kg  
sedation to mL/hr
induction  to mL 
maintenance to mL/hr

Recommended IV Dosages*

Sedation 25-100 mcg/kg/min

Induction 1-2.5 mg/kg

Maintenance 50-200 mcg/kg/min


1)  The doctor has decided to intubate your 100 kg patient who has gone into acute respiratory distress.  As the doctor prepares to intubate, he asks you to give 2.5 mg/kg of propofol (10 mg/mL) IVP.  How many milliliters of propofol will you give?  Using the formula provided on the IV dosage calulator page,

dose ordered = 2.5 mg x 100 kg = 250 mg
dose available = 10 mg
volume available = 1 mL

dose ordered / dose available x volume available

The answer is 25 mL
250 / 10 x 1 = 25

2)  Calculate an IV a maintenance infusion of propofol (10 mg/mL) on a patient weighing 80 kilograms via a volumetric IV pump that delivers in mL/hr.   For our purposes, use the lower limit of 50 mcg/kg/min.  The following steps are found on the mcg/kg/min as mL/hr page.  

First convert mcg/kg/min into mg/hr.  Use the formula below.

(mcg x kg) / 1000 x 60

Using 50 mcg and 80 kg in this formula results in an dosage of 240 mg.
50 x 80 = 4000
4000 / 1000 x 60 = 240

Next, use the formula below to solve the rest of the problem.
In this example, 
240 mg become the dose ordered,
10 mg is the dose available,
1 mL is the volume available.

dose ordered / dose available x volume available

The answer is 24 mL/hr.
240/10 x 1 = 24

A brief description of propofol can be found at GlobalRPH

*Morgan & Mikhail (1996).


This page is intended for educational purposes. The author of this page has carefully checked that the dosage information on this page is accurate and in accord with the standards accepted at the time this page was printed. Readers are advised, however, to check the product information currently provided by the manufacturer to be certain that changes have not been made in the recommended dose. The author cannot be responsible for misuse or misapplication of the material on this page.


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